Optibac Probiotics Bifido & Fibre - Vegan Digestive Probiotic Supplement with FOS Fibre to Maintain Regularity & 25 Billion Bacterial Cultures - 30 Sachets

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Dimidi E, Zdanaviciene A, Christodoulides S, et al. Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation. Aliment Pharmacol Ther. 2019;49(3):251-264. View abstract. Schiavi E, (2016) The surface associated exopolysaccharide of Bifidobacterium longum35624 plays an essential role in dampening host pro-inflammatory responses and in repressing local TH17 responses. Appl Environ Microbiol.Oct 7. Namba, K., Hatano, M., Yaeshima, T., Takase, M., and Suzuki, K. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci.Biotechnol.Biochem. 2010;74(5):939-945. View abstract.

Iwabuchi N, Hiruta N Kanetada S Yaeshima T Iwatsuki K Yasui H. Effects of Intranasal Administration of Bifidobacterium longum BB536 on Mucosal Immune System in Respiratory Tract and Influenza Virus Infection in Mice. Milk Science 2009;38(3):129-133.Wang, L. & Wise, M. J. Glycogen with short average chain length enhances bacterial durability. Die Naturwissenschaften 98, 719–729, doi: 10.1007/s00114-011-0832-x (2011). Sommerfield D. et al (2003), ‘Influence of Bifidobacterium infantisfeeding on secretagogue response and gut barrier function in rats recovering from colitis’, Gastroenterology,124:A311 Puccio, G., Cajozzo, C., Meli, F., Rochat, F., Grathwohl, D., and Steenhout, P. Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics. Nutrition 2007;23(1):1-8. View abstract.

Al Faleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2014;(4):CD005496. View abstract. Davidson SJ, Barrett HL, Price SA, Callaway LK, Dekker Nitert M. Probiotics for preventing gestational diabetes. Cochrane Database Syst Rev. 2021;4(4):CD009951. View abstract. Mohamad Nor MH, Ayob N, Mokhtar NM, et al. The effect of probiotics (MCP(®) BCMC(®) Strains) on hepatic steatosis, small intestinal mucosal immune function, and intestinal barrier in patients with non-alcoholic fatty liver disease. Nutrients 2021;13(9):3192. View abstract.

Lugli, G. A. et al. Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics. Applied and environmental microbiology 80, 6383–6394, doi: 10.1128/AEM.02004-14 (2014).

Goodman C, Keating G, Georgousopoulou E, Hespe C, Levett K. Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis. BMJ Open 2021;11(8):e043054. View abstract. Frech T.M. et al (2011). Probiotics for the treatment of systemic sclerosis-associated gastrointestinal bloating/distension . Clin Exp Rheumatol, 29(2 Suppl 65):S22-5. Jayasimhan S, Yap NY, Roest Y, Rajandram R, Chin KF. Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2013;32(6):928-34. View abstract.Chang K., et al (2005), ‘Modulation of cytokine profiles in healthy and IBS subjects following supplementation with the unique probiotic strain, Bifidobacterium infantis35624’, P&G Health Sciences Institute Publication 2005, Gastroenterology,128, (4 Suppl 2) pp.A661 Roberfroid MB. Prebiotics and probiotics: are they functional foods? Am J Clin Nutr. 2000;71(6 Suppl):1682S-7S; discussion 1688S-90S. View abstract. Bairead E. el al.(2005), 'Alterations in immunological gene expression from colonic biopsies in female IBS patients following probiotic consumption'. Gastroenterology, 128(44) Guardamagna O, Amaretti A, Puddu PE, et al. Bifidobacteria supplementation: effects on plasma lipid profiles in dyslipidemic children. Nutrition. 2014;30(7-8):831-6. View abstract.

Christian Milani, Gabriele Andrea Lugli, Sabrina Duranti, Leonardo Mancabelli, Chiara Ferrario, Marta Mangifesta, Alice Viappiani, Stefania Arioli & Marco Ventura Cremonini F, Di Caro S, Covino M, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002;97:2744-9. View abstract. O’Callaghan L. et al (2002), ‘Human cytokine production by mesenteric lymph node cells in response to probiotic and pathogenic bacteria’, Gastroenterology,122: A151 Chen K-S, et al (2005), ‘Oral administration with a unique probiotic strain, Bifidobacterium infantis35624, to IBS subjects normalizes their systemic immunological imbalance in cytokine profile toward healthy subjects’, Can J Gastroenterol. 19 (Suppl SB):R.1112.Chi C, Li C, Buys N, Wang W, Yin C, Sun J. Effects of probiotics in preterm infants: A network meta-analysis. Pediatrics. 2021;147(1):e20200706. View abstract. Research so far suggests use is safe for most children and adults with normal, healthy immune systems minus a few potential side effects. Research has documented several reported cases of severe infection due to probiotic consumption. However, these people had weakened immune systems. Xiao, J. Z., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Iwatsuki, K., Kokubo, S., Togashi, H., Enomoto, K., and Enomoto, T. Effect of probiotic Bifidobacterium longum BB536 [corrected] in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo-controlled trial. J Investig.Allergol.Clin.Immunol. 2006;16(2):86-93. View abstract.