return data for the test standard FASP-S05: turnaround time and test standard FASP-S06: inadequate samples ( KPI FA4) Screening for 11 physical conditions as part of the 20-week scan is offered to all pregnant women and takes place between 18⁺⁰ and 20⁺⁶ weeks of pregnancy. Scans can be completed up to 23⁺⁰ weeks of pregnancy. Conditions screened for

Please be aware that this data covers the period through the coronavirus (COVID-19) pandemic. Provider performance should therefore be interpreted with caution. To enable timely reporting of screening test results to women so they can make personal informed choices. Definition Numerator: number of eligible women for whom a completed screening result was available from the screening scan (18 weeks plus 0 days to 23 weeks plus 0 days of pregnancy) at the day of report. Please be aware that this data covers the time period through the COVID-19 pandemic. Provider performance should therefore be interpreted with caution.are offered an appointment within the optimal gestational screening timeframe but choose to attend at a different time for personal reasons Women who decline is the number of eligible women who are offered screening and make a personal informed choice not to accept screening, including women who choose to have private screening and do not wish to have NHS screening. Performance thresholds out of 139 screening services submitted data, including 57 services that reported zero couples at risk.

All screening services who submitted data (136 out of 136) met the acceptable threshold of 90%, with 133 meeting the achievable threshold of 95% and 12 of them reporting performance of 100%.

National performance of ST4a in Q4 was 52.9%, the highest ever level recorded for this KPI. The national trend graph below shows the ST4a performance since the KPI was first published from 1 April 2019. Thresholds have not yet been set for this KPI. The FASP handbook brings together national guidance, information and processes that relate to the FASP screening pathways. Screening for Edwards’ syndrome and Patau’s syndrome is offered to all eligible pregnant women and takes place between 10⁺⁰ and 14⁺¹ weeks of pregnancy. NIPT is now offered following a higher chance result (between 1 in 2 and 1 in 150) from either the combined or quadruple test in both singleton and twin pregnancies. Numerator: number of women with a higher chance result offered an appointment within 3 working days

This report should be read in conjunction with the full key performance indicator ( KPI) data tables published each quarter. 1. Fetal anomaly screening 1.1 KPI FA2: coverage: fetal anomaly ultrasound out of 142 screening services submitted data, including 65 services that reported zero women at risk.

These requirements relate to the process of following-up women with higher chance results who wish to have PND. Denominator: number of samples received for karyotype testing where the indication for genetic testing is a suspected or confirmed anomaly detected on the 18 weeks plus 0 days to 20 weeks plus 0 days fetal anomaly ultrasound undertaken in the reporting period. National performance of FA2 in Q1 2020 to 2021 was 99.3%, the highest ever level recorded for this key performance indicator (KPI0. FA2 is collected 6 months (2 quarters) in arrears. The national trend graph below shows that FA2 performance has remained above the achievable threshold of 95% since 1 April 2017. Denominator: number of pregnant women booked for antenatal care during the reporting period, excluding women who:

Numerator: number of women referred to a tertiary centre and seen on or before 5 working days of the screening scan. Please be aware that this data covers the time through the COVID-19 pandemic. Provider performance should therefore be interpreted with caution. To provide assurance that screening is offered to everyone who is eligible and each woman who accepts screening has a conclusive screening result. Definition

Date standard last updated: April 2018 FASP-S03a: test: screen positive rate T21, T18, T13 screening Description Local referral is defined as a referral within the same provider organisation (this includes a local fetal medicine service). S08b - tertiary referrals A single repeat scan must be offered and completed by 23 weeks plus 0 days. The woman can be rescanned on the same day and if the scan is still incomplete, a new appointment should be offered according to local guidelines. The eligibility criteria for entry into the combined screening pathway is a baby’s CRL measurement between 45.0mm and 84.0mm. This is equal to 11 weeks plus 2 days to 14 weeks plus 1 day of pregnancy.