In one of the links below the interesting idea that cancer cells are unable to properly metabolize lactate is introduced. If true, then this could offer a less technically difficult route to glucose withdrawal; simply remove the glucose and add in lactate. Some of the other approaches try to remove glucose from the body but then must find work around for the heart and brain. Eliaguov, J.; Gopal, N.; Dixon, A.; Choudhury, M.; Konno, S. Potentiation of Anticancer Effect by Combination of Mushroom extract and Grapeseed extract on human Bladder cancer cells. Cancer Sci. Res. 2021, 4, 1–12. [ Google Scholar] [ CrossRef] A similar observation comes from vegetal biology: plants secure their access to light and nutrients by suppressing their close competitors. They achieve this by releasing HDAC inhibitors in the rhizosphere. These inhibitors (Benzoxazinoids), for example DIBOA, are cyclic hydroxamic acids structures, which are further degraded into more stable compounds with HDAC activity [ 17] limiting the development of competitors, presumably through some similarities with indole auxins. This book tells my story, the story of a carefree man leaving a happy life in Miami, who suddenly falls into the nightmare of the disease whose just name scares cancer. Mine is incurable, or rather all of mine because the prostate, bones and lymph nodes are affected. Despite the terrible prognosis from my oncologists, I have decided that I will not die of cancer. Do you think that's impossible? Yet I should be dead by the time of this writing. The point is, I have never felt this good in years and my latest results point to remission!

Kroemer, G.; Pouyssegur, J. Tumor cell metabolism:cancer’s Achilles’ heel. Cancer Cell. 2008, 13, 472–482. [ Google Scholar] [ CrossRef] Quite a few drugs for cancer are developed from non natural substances. Many thousands of natural chemicals were tried and tested before the first chemo drug came along, and Docetaxel was derived from Yew tree sap. Maybe its made in a lab now. But having Psa at 0.1 does not mean he has remission. After 4 doses of Lu177 my Psa went from 25 before Lu177 to 0.32 at 12 months later in Nov 2019r, and doctors were amazed, but I have always known that to be due to Xtandi working, because I had begun it in April 2019. Nearly 3 years after being diagnosed with inoperable metastatic cancer, our patient shows no signs of disease and leads a full and active life.Liu, R.; Liu, P.; Bi, H.; Ling, J.; Zhang, H.; Zhang, M.; Hu, Y.; Chiao, P.J.; Huang, P.; Liu, J. Malignant transformation by oncogenic K-ras requires IDH2-mediated reductive carboxylation to promote glutamine utilization. Cancer Commun. 2022. Epub ahead of print. [ Google Scholar] [ CrossRef] One anomaly I cannot understand though is that his PSA has been at below 0.1 for over a year now and yet he still has a prostate. How is this possible? Reid, R.T.; Live, D.H.; Faulkner, D.J.; Butler, A. A siderophore from a marine bacterium with an Exceptional ferric ion affinity constant. Nature 1993, 336, 455–458. [ Google Scholar] [ CrossRef] Gonçalves, J.M.; Barcellos Silva, C.M.; Rivero, E.R.C.; Cordeiro, M.M.R. Inhibition of Cancer stem cells promoted by Pimozide. Clin. Exp. Pharmacol. Physiol. 2019, 46, 116–125. [ Google Scholar] [ CrossRef][ Green Version]

Fiorillo, M.; Peiris-Pagès, M.; Sanchez-Alvarez, R.; Bartella, L.; Di Donna, L.; Dolce, V.; Sindona, G.; Sotgia, F.; Cappello, A.R.; Lissanti, M.P. Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-Signaling and mitochondria metabolism. BBA-Bioenerg. 2018, 1859, 984–996. [ Google Scholar] [ CrossRef] I truly believe the guy (no pun intended) is legit as he doesn’t sell anything and you see how his body has changed over the past two years (white hair became grey, went from heavy set to skinny, etc…) and he also makes all of his documents (MRI, Scans, etc…) available for all to view on Google Drive.

Zhang, Y.-F.; Zhang, H.; He, L.; Liu, C.; Xu, Y.; Qian, P.-Y. Butenolide Inhibits Marine Fouling by altering the primary metabolism of three target organisms. ACS Chem. Biol. 2012, 7, 1049–1058. [ Google Scholar] [ CrossRef] [ PubMed] Huang, C.K.; Chang, P.H.; Kuo, W.H.; Chen, C.L.; Jeng, Y.M.; Chang, K.G.; Shew, J.-Y.; Hu, C.-M.; Lee, W.-H. Adipocytes promote Malignant growth of breast tumors with monocarboxylate transporter 2 expression via Beta-Hydroxybutyrate. Nat. Commun. 2017, 8, 14706. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] These are my personal choices. 1 cup of V8 juice is good lycopene for a meal, 16 mg. Try to get total daily lycopenes around 50-70mg. watch out for sodim intake. Also consider around 10-20 mg per meal total. I go through a lot of catsup. Lithostat acetohydroxamic acid is a typical SCOT inhibitor used to treat bladder stones. Another inhibitor, Pimozide [ 40, 41], used to treat mental diseases, reduces cancer incidence. Several interesting compounds are highlighted in the work of Lissanti’s group, who describe potential SCOT inhibitors, the Mitoketoscine [ 42], through their structural and binding properties. Selecting the best and least toxic derivative for animal cancer models requires collaboration with pharmaceutical groups.

If using fasting as a strategy to lower glucose and glutamine, I was told that it takes 2 days to deplete glutamine levels and another 2 days to really start killing cancer cells. So, perhaps your fasts weren't long enough in duration. Prof Seyfried indicates that after 14 days he has not seen any cancer surviving in the patients he has been studying. I am gearing up to try a 4-7 day fast soon and hoping that will be enough.Schwartz, L.; Abolhassani, M.; Guais, A.; Sanders, E.; Steyaert, J.M.; Campion, F.; Israël, M. A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results. Oncol. Rep. 2010, 23, 1407–1416. [ Google Scholar] [ CrossRef][ Green Version] Cassim, S.; Vučetić, M.; Ždralević, M.; Pouyssegur, J. Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or replace Fermentative Glycolysis in Cancer. Cancers 2020, 12, 1119. [ Google Scholar] [ CrossRef] [ PubMed] Benjamin, D.; Robay, D.; Hindupur, S.K.; Pohlmann, J.; Colombi, M.; El-Shemerly, M.Y.; Maira, S.-M.; Moroni, C.; Lane, H.A.; Hall, M.N. Dual inhibition of Lactate transporters MCT1and MCT4 is synthetic lethal with metformin, due to NAD+Depletion in cancer cells. Cell Rep. 2018, 25, 3047–3058. [ Google Scholar] [ CrossRef][ Green Version] Quite a few men get Pca which is very weak, and easily defeated by say ADT + EBRT, and I've known men like that. But 2 years of ADT + 70Grey EBRT 1/2 way along was supposed to work, but after quitting ADT to see if it had worked, Psa went up from 0.08 to 8 in 6 months, so I have needed ADT ever since.

Yoshino, M.; Miyajima, E.; Tsushima, K. Kinetics of the interactions of AMP Deaminase with Fatty acids. J. Biol. Chem. 1979, 254, 1521–1525. [ Google Scholar] [ CrossRef] Konishi, Y.; Kobayashi, S.; Shimizu, M. Tea Polyphenols inhibit the Transport of Dietary Phenolic Acids Mediated by the Monocarboxylic Acid Transporter (MCT) in Intestinal Caco-2 Cell Monolayers). J. Agric. Food Chem. 2003, 51, 7296–7302. [ Google Scholar] [ CrossRef] [ PubMed]The next two urls are large scale fasting studies that showed that these approaches are quite safe though the studies were not constructed to screen for cancer patients. Water only fasting over prolonged periods does appear to have substantial potential for cancer therapy. Okumura, S.; Konishi, Y.; Narukawa, M.; Sugiura, Y.; Yoshimoto, S.; Arai, Y.; Sato, S.; Yoshida, Y.; Tsuji, S.; Uemura, K.; et al. Gut bacteria Identified in colorectal cancer patients promote tumorigenesis via butyrate secretion. Nat. Commun. 2021, 12, 5674. [ Google Scholar] [ CrossRef]