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The effect of pectin on prostate cancer cell lines has been studied in vitro. Studies found that MCP decreased PCa cell survival and simultaneously increased their susceptibility to infrared radiation (IR) in a dose-dependent manner. However, a slight decrease in the G0/G1 phase was caused by MCP, leading to substantial cell arrest in G2. In addition, MCP was found to increase the production of the pro-apoptotic protein Bax and cleavage of the CASP3 precursor. Moreover, apoptosis suppression, angiogenesis, adhesion, motility, and invasion were significantly decreased with the combined use of MCP and IR, whereas MCP alone had no effect. It has been proposed that Gal-3 downregulation and inhibition of its anti-apoptotic effect cause the enhanced radiosensitivity and cell death observed with combined MCP and IR treatment. Further evidence suggests that the combination of MCP-mediated Gal-3 inhibition and the functions of Gal-3 in tissue remodeling and fibrosis may reduce the adverse effects of radiation treatment [ 48]. Modified Citrus Pectinhas had the long pectin molecules broken into smaller pieces, each of which remains a polysaccharide. Polysaccharides are known to be important in cellular communication and in boosting the immune system. S. Conti, et al., “Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer,” Integr. Cancer Ther. 17(4), 1225–1234 (2018). Nutritional Supplements by Nutricentral.co.uk - information and products are not intended to diagnose, treat, cure, or prevent any disease Pectin isa soluble fibre, which cannot be absorbed into the body. Apolysaccharide, the body cannot break it down into its constituent molecules. Typically, it is found in the cell wall of plants, vegetables and fruits - like apples, carrots and in the peel of citrus fruit and plums.
The pectin found in many fruits cannot be absorbed into the bloodstream due to its large molecular size. Only PectaSol-C MCP is produced using a proprietary process that carefully controls the weight and structure of the pectin molecules. The result is Modified Citrus Pectin with a specific low molecular weight range less than 15 kilodaltons and a low degree of esterification. This means that it is readily and effectively absorbed into the bloodstream, where it can actively promote cellular wellness. Extracellular Gal-3 acts as an adhesion surface protein, forming lattices with itself, binding glycoproteins and glycolipid membrane receptors and creating a gel-like biofilm that anchors other procancerous growth factors and inflammatory compounds within the extracellular matrix.Optimal therapy of biochemically relapsed prostate cancer (BRPC) after local treatment is elusive. An established modified citrus pectin (PectaSol ®, P-MCP), a dietary polysaccharide, is an established antagonist of galectin-3, a carbohydrate-binding protein involved in cancer pathogenesis. Based on PSA dynamics, we report on the safety and the primary outcome analysis of a prospective phase II study of P-MCP in non-metastatic BRPC based. Sixty patients were enrolled, and one patient withdrew after a month. Patients ( n = 59) were given P-MCP, 4.8 grams X 3/day, for six months. The primary endpoint was the rate without PSA progression and improved PSA doubling time (PSADT). Secondary endpoints were the rate without radiologic progression and toxicity. Patients that did not progress by PSA and radiologically at six months continued for an additional twelve months. After six months, 78% ( n = 46) responded to therapy, with a decreased/stable PSA in 58% ( n = 34), or improvement of PSADT in 75% ( n = 44), and with negative scans, and entered the second twelve months treatment phase. Median PSADT improved significantly ( p = 0.003). Disease progression during the first 6 months was noted in only 22% ( n = 13), with PSA progression in 17% ( n = 10), and PSA and radiologic progression in 5% (n = 3). No patients developed grade 3 or 4 toxicity. The incidence and severity of adverse drug-related reactions were modest and reversible, and most patients stayed on treatment per protocol. These findings are consistent with the FDA classification of P-MCP as GRAS and support that this compound is appropriate for long-term treatment. The most well-established pathogenic role of Gal-3 is in the development and migration of cancer. Gal-3 is over-expressed on the surface of cancer cells, acting as the primary adhesion molecule that allows cancers to proliferate, metastasize and evade the immune system.
To find out more about MCP treatment and its potential health benefits, we’ll take a closer look at the research we have so far. Rabbani GH, Teka T, Saha SK, Zaman B, Majid N, Khatun M, et al. Green banana and pectin improve small intestinal permeability and reduce fluid loss in Bangladeshi children with persistent diarrhea. Dig Dis Sci. 2004 Mar;49(3):475–84. DOI: 10.1023/b:ddas.0000020507.25910.cf. PMID: 15139502.Xu L, Yu W, Jiang J, Feng X, Li N. [Efficacy of pectin in the treatment of diarrhea predominant irritable bowel syndrome]. Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Mar;18(3):267–71. PMID: 25809332. Azémar M, Hildenbrand B, Haering B, Heim ME, Unger C. Clinical Benefit in Patients with Advanced Solid Tumors Treated with Modified Citrus Pectin: A Prospective Pilot Study. Clin Med Oncol. 2007 Jan;1:CMO.S285. DOI: 10.4137/CMO.S285. Hopefully, this dietary supplement will ultimately be one that lives up to its promise. In the meantime, we will continue to keep an eye on all this has to offer. Today, Gal-3 heralds one of the fastest growing fields of medical research, with compelling new data and large-scale studies continuing to highlight the mechanisms by which the overexpression of Gal-3 acts as an upstream initiator for an exhaustive range of pathogenic processes. Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, et al. The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Altern Ther Health Med. 2008 Aug;14(4):34–8. PMID: 18616067.
October 29, 2021 Dr. Michael Ruscio, DC is a clinician, Naturopathic Practitioner, clinical researcher, author, and adjunct professor at the University of Bridgeport. His work has been published in peer-reviewed medical journals and he speaks at conferences around the globe. Modified Citrus Pectin Benefits for Heavy Metal Detox and Beyond
Modified citrus pectin has also shown promise in oncology. Studies have found that this dietary supplement may stop cancer cells from spreading [ 8, 9]. It keeps the proliferation of cancer cells down both in vitro (test tube) and in vivo (within the living). This is thought to be due to MCP’s ability to cause apoptosis (cell death) in these tumor cells. The natural history of men with biochemically relapsed, non-castrate prostate cancer is quite mixed. They may remain asymptomatic and free of clinical evidence of disease for many years [ 4]. Extensive data on patients’ natural history of relapsing after surgery and after curative radiotherapy indicate that the PSA doubling time (PSADT) predicts the probability of metastasis-free and prostate cancer-specific survival [ 5, 6, 7, 8, 9, 10, 11]. PSADT of <3 months, 3.00-8.99 months, and ≥nine months may be associated with poor, intermediate, and good prognosis in disease progression and development of overt metastatic disease. Furthermore, the Prostate-Specific Antigen Working Group’s guidelines on PSADT determined that clinical evidence supports PSADT as a predictive marker of cancer progression among post-local therapy prostate cancer patients experiencing biochemical recurrence [ 12]. Thus, PSADT has been used in our study design to define endpoints. D. Keizman, et al., Effect of Pectasol-C Modified Citrus Pectin (P-MCP) Treatment (tx) on PSA Dynamics in Non-Metastatic Biochemically Relapsed Prostate Cancer (BRPC) Patients (pts): Results of a Prospective Phase II Study,” J. Clin. Oncol. 36(6), 14 (2018).
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