The UL for niacin is 35 mg/day. This level was determined because 30-50 mg of niacin in the form of nicotinic acid may cause flushing. However, the niacinamide (also known as nicotinamide) form of niacin is not associated with flushing, and adverse effects have only been shows with doses much higher than this (typically 500 mg/day or more).

Without enough sleep or exercise, every system in the body is affected, and the absorption of methyl-related nutrients is no exception. It won’t provide a solution to feeling energy deprived on its own. That’s why taking an overall holistic approach when considering the impact of supplements is vital. Methylated Vitamins Can Help You, and You Can Help ThemIt’s important to ensure that no nutrients in your multivitamin exceed the upper limit as established by the National Institute of Health Office of Dietary Supplements. Research has shown that methylcobalamin plays a vital role in energy production, nerve function, and cognitive health. It also supports methylation, which is critical for efficient cellular function and DNA synthesis. Ebrahimi E, Khayati Motlagh S, Nemati S, Tavakoli Z. Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms. J Caring Sci. 2012;1(4):183-189. Published 2012 Nov 22. doi:10.5681/jcs.2012.026 Fortunately, medical technology has progressed far enough to offer methylated vitamins. In fact, for most professional level supplement providers, methylated vitamins have been the standard for some time, and the retail space has caught up. This is good news, and not only for those with the MTHFR mutation. Everyone can benefit from the active state of methylated vitamins. The Power of Active Vitamins Methylation is key to immune regulation and repair. Many studies link high homocysteine and genetic factors affecting methylation, to autoimmune conditions in general.

This product is certified vegan, Non-GMO Project Verified, NSF Certified Gluten-Free, and has been tested and approved through ConsumerLab.com's voluntary certification program, and was included in ConsumerLab.com's 2023 B Vitamin Supplements Review. In addition to the organic food blend, this supplement has an added raw probiotic and enzyme blend which some people may not want or need. Therefore, we recommend to ask a healthcare professional before taking this supplement especially if you are on any medication. Nutrient absorption: Some nutrients may decrease the absorption of others. Iron and calcium compete for absorption, which is why most quality multivitamins will have one but not both. The mineral you need will depend on your diet. High doses of iron may also inhibit zinc absorption. Depression, anxiety, PMS, PMDD, post-partum depression, chronic fatigue and fibromyalgia. Pregnancy can exacerbate a B12 deficiency because high amounts of B12 are needed by the fetus, thus leaving the woman more depleted than she was pre-pregnancy and setting her up for post-partum depression. We are a big fan of many of Thorne's products since they prioritize quality and often have third-party certifications. The Basic Nutrients 2/Day is no exception—it covers the multivitamin bases without unnecessary extra herbs or enzymes found in many multivitamins on the market. It's also NSF Certified for Sport, a robust credential that verifies supplement contents and ensures it is free of unsafe levels of contaminants and substances banned for athletes. MTHFR 677TT = a homozygous variant which is two variants – this is what I have and I def have some issues

What do B complex vitamins do?

While methylated vitamins are generally safe, some individuals may experience side effects such as headaches, nausea, or gastrointestinal discomfort. It is important to work with a healthcare professional for personalized vitamin recommendations to reduce the risk of side effects. Can methylated vitamins be taken with other supplements or medications? You may find yourself with high mercury, or high copper, or high other heavy metals….though not always. High copper can cause low iron levels. MTHFR 1298CC = a homozgyous variant which is two variants – will cause more issues than just one mutation