Review questions and review protocols must be clear and focused and build on the draft questions listed in the scope. They provide the framework for the design of the literature searches, inform the planning, methods and process of the evidence review, and act as a guide for the development of recommendations by the committee. Review protocols may also be used to inform surveillance of guidelines, and future updates (see the chapters on ensuring that published guidelines are current and accurate and updating guideline recommendations). Where the Pico makes the biggest difference is that on the Quest 2 the system is not accessible without first logging into Facebook. Sound The face mask of the headset is made of a comfortable and soft PU material. PU stands for ”PolyUrethane” and ensures that sweat is not absorbed into the face mask. The face mask is also easy to clean, which is a great advantage over other materials in the days of Covid-19. Overall, the Pico 4 is a great device – and worthy of a place on our best VR headsets list – but it sometimes feels like a work in progress. The issues aren't enough to make the headset bad in its own right, but they are enough to make the race between the Pico 4 and Quest 2 feel much closer than it should be. What are the symptoms and signs of urinary tract infection (UTI) in babies, children and young people under 16 years old?

which outcomes reported in studies of interventions are most important to people using services, family members or carers or the public Finally, we look at the streaming options of the headset. Standalone VR has many advantages; The headset is not connected with cables, so there is a large degree of freedom, use at different locations is simple and the headset is easy to transport and set up. However, it cannot be denied that connecting a VR headset to a PC still offers the most reliability. Fortunately, Pico has also thought of this, due to a built-in streaming application within the Neo 3 Pro series. The streaming application is built on the Boundless XR platform, which supports both wireless and wired streaming via a USB Type-C to Type-C cable. Collins G, Reitsma J, Altman D et al. (2015) Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. Annals of Internal Medicine 162: 55–63

The best budget VR headset? Not for sure

When the effectiveness of a medicine is being considered, it is expected that the evidence review will include medicines safety outcomes, such as adverse events. These outcomes are also likely to be included as part of assessing the overall impact on quality of life in any cost-effectiveness analysis, or as part of supporting shared decision making. What you won’t be getting, of course, is the same content library. As we’ll detail in a second, some of Quest 2’s best games are on the Neo 3 Link, but you obviously won’t have access to Meta-exclusive titles like Resident Evil 4 VR and Medal of Honor: Above and Beyond. It remains to be seen if Pico might support Neo 3 Link with its own exclusive software, though the company says there’s around 200 pieces of content on the device right now.

Lifestyle interventions through participatory research: a mixed methods systematic review of alcohol and other breast cancer behavioural risk factors: what works and how? (Thomas 2022) Craig P, Cooper C, Gunnell D et al. on behalf of the MRC (2011) Using natural experiments to evaluate population health interventions: new Medical Research Council guidance. London: Medical Research Councilb) What can be inferred from the qualitative synthesis of healthcare professionals' experiences or views that can explain the effects of clinical supervision or inform its appropriateness and acceptability for health professionals? For each review question, factors that may affect the outcomes and effectiveness of an intervention, including any wider social factors that may affect health and any health inequalities, should be considered (see the section on considering health inequalities when preparing review protocols). Outcomes (on both benefits and harms) and other factors that are important should be specified in the review protocol. In general, a range of 5 to 9 outcomes should be defined. Guidance on prioritising outcomes is provided by the GRADE working group. Martin P, Lizarondo L, Kumar S, Snowdon D (2021) Impact of clinical supervision on healthcare organisational outcomes: A mixed methods systematic review. PLoS ONE 16(11): e0260156 Justice AC, Covinsky KE, Berlin JA (1999) Assessing the generalizability of prognostic information. Annals of Internal Medicine 130: 515–24

What are the patterns of physical activity among children from different populations and of different ages in England? Review questions about pharmacological interventions will usually only include medicines with a UK marketing authorisation, based on regulatory assessment of safety and efficacy. Use of a licensed medicine outside the terms of its marketing authorisation (off-label use) may be considered in some circumstances; for example, if this use is common practice in the UK, if there is good evidence for this use, or if there is no other medicine licensed for the indication. Off-label use is particularly common in pregnant women and in children and young people because these groups have often been excluded from clinical trials during medicine development. Which scoring tools for signs and symptoms (including Centor and FeverPAIN) are most accurate in predicting sore throat caused by group A beta-haemolytic streptococcus infection in primary care?

When designing review questions and protocols, it is important to consider possible intercurrent events (events that occur after starting treatment and either preclude the observation of the variable, or affect its interpretation, such as death, non-adherence to treatment or stopping treatment) and how these will be dealt with in any analysis in the guideline, if different identified studies analyse the data in different ways. Clinical trials are increasingly following the Estimand framework (European Medicines Agency), which attempts to increase the clarity of the precise treatment effect that an individual study is estimating.