Thanos SM, Halliday GM, Damian DL. Nicotinamide reduces photodynamic therapy-induced immunosuppression in humans. Br J Dermatol. Sep 2012;167(3):631-636. Some supplements that contain vitamin B3 only list niacin, but most supplements specify the form of niacin as either nicotinic acid or niacinamide. Safety considerations: Rash, stomach upset, elevated liver enzymes (at more than 3 grams (g) per day, though this is rare), thrombocytopenia (in people who have renal disease and are on dialysis). Polo V, Saibene A, Pontiroli AE. Nicotinamide improves insulin secretion and metabolic control in lean type 2 diabetic patients with secondary failure to sulphonylureas. Acta Diabetol 1998;35:61-4. View abstract.

Nicotinamide | Drugs | BNF | NICE

Nicotinamide has anti-inflammatory properties, which may be used for the treatment of bullous (blistering) diseases. In high-risk individuals, nicotinamide supplementation had protective effects against certain types of skin lesions and nonmelanoma skin cancers . D'Andrea E, Hey SP, Ramirez CL, Kesselheim AS. Assessment of the role of niacin in managing cardiovascular disease outcomes: a systematic review and meta-analysis. JAMA Netw Open. 2019;2(4):e192224. doi:10.1001/jamanetworkopen.2019.2224 Swash M, Roberts AH. Reversible pellagra-like encephalopathy with ethionamide and cycloserine. Tubercle 1972;53:132. View abstract.

How does nicotinamide work?

Niacinamide, also called nicotinamide, is a form of vitamin B3. It's found in many foods including meat, fish, milk, eggs, green vegetables, and cereals. Kharitonova T, Shvarts YG, Verbovoy AF, Orlova NS, Puzyreva VP, Strokov IA. Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (CYLINDER). BMJ Open Diabetes Res Care 2022;10(3):e002785. View abstract. Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide on osteoarthritis: a pilot study. Inflamm Res 1996;45:330-4. View abstract.

Nicotinamide Prevents Common Skin Cancers in High-Risk Oral Nicotinamide Prevents Common Skin Cancers in High-Risk

That’s because a deficiency of vitamin B3 or tryptophan leads to a disease called pellagra, which is characterized by the four D’s — diarrhea, dermatitis, dementia and, if left untreated, death ( 3). Thompson BC, Surjana D, Halliday GM, et al. Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes. Exp Dermatol. Jul 2014;23(7):509-511. Rolfe HM. A review of nicotinamide: treatment of skin diseases and potential side effects. J Cosmet Dermatol. Dec 2014;13(4):324-328. Nicotinamide gel is marketed as an over-the-counter treatment for acne in Canada, Australia, NZ, UK, USA and Ireland. If a twice-daily application causes excessive drying of the skin, one may reduce to once a day, or every other day. RosaceaNiacinamide is a form of vitamin B3, a water-soluble vitamin. This means that vitamin B3 and other water-soluble vitamins can dissolve in water. Powell ME, Hill SA, Saunders MI, Hoskin PJ, Chaplin DJ. Human tumor blood flow is enhanced by nicotinamide and carbogen breathing. Cancer Res. 1997;57(23):5261-4. View abstract. Greenbaum CJ, Kahn SE, Palmer JP. Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM. Diabetes 1996;45:1631-4. View abstract.

Nicotinamide | Memorial Sloan Kettering Cancer Center Nicotinamide | Memorial Sloan Kettering Cancer Center

High doses of niacin can cause niacin flush, which appears as red skin that may itch or burn. This article explains what this is and whether it’s… READ MORE Brain tumor. Taking niacinamide by mouth while undergoing chemotherapy doesn't seem to benefit people with brain tumors. Placebo-controlled trials have suggested high-risk sun-damaged patients taking oral nicotinamidewho have extensive actinic keratoses and cutaneous squamous cell carcinomasmay expect a reduction in the number of new lesions over time. The evidence is inconclusive. Adverse effects of oral nicotinamideNijkamp MM, Span PN, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende PL, de Jong M, van der Kogel AJ, Bussink J, Kaanders JH. Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial. Eur J Cancer. 2013 Oct;49(15):3202-9. View abstract. Centre for Clinical Practice at NICE (UK). Hyperphosphataemia in Chronic Kidney Disease: Management of Hyperphosphataemia in Patients with Stage 4 or 5 Chronic Kidney Disease. National Institute for Health and Care Excellence: Clinical Guidelines. Manchester: National Institute for Health and Care Excellence (UK); 2013 Mar.

Niacinamide: Uses, Benefits, Side Effects - Verywell Health

Khodaeiani E, Fouladi RF, Amirnia M, Saeidi M, Karimi ER. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. Int J Dermatol. 2013 Aug;52(8):999-1004. View abstract. Hyperphosphatemia treatment: Hyperphosphatemia occurs when the blood has a high phosphate level. It's one of the most common complications of chronic kidney disease. A meta-analysis found oral (by mouth) niacinamide supplements to be safe and effective in reducing blood levels of phosphate in people receiving dialysis for chronic kidney disease. Monfrecola G, Gaudiello F, Cirillo T, et al. Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-alpha gene expression in HaCaT keratinocytes after ultraviolet B irradiation. Clin Exp Dermatol. Mar 2013;38(2):185-188. Vitamin B3 is generally found as niacinamide in animal-based products, such as meat and poultry, and as nicotinic acid in plant-based foods like nuts, seeds and green vegetables ( 2). Osteoarthritis. Taking niacinamide by mouth seems to improve joint flexibility and reduce pain and swelling in people with osteoarthritis.Olmos PR, Hodgson MI, Maiz A, et al. Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics. Diabetes Res Clin Pract. 2006;71(3):320-33. View abstract. Hoskin PJ, Rojas AM, Phillips H, Saunders MI. Acute and late morbidity in the treatment of advanced bladder carcinoma with accelerated radiotherapy, carbogen, and nicotinamide. Cancer. 2005;103(11):2287-97. View abstract. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with NIACINAMIDE Niacinamide and nicotinic acid (aka niacin) are common forms of vitamin B3 in supplements. Your body can convert tryptophan from food into niacinamide as needed, and it may make niacinamide from niacin to an extent when there's enough of it.